The Heavenly Cow from which all life flows.
This drawing is a reproduction of the interior back panel of the Gilded Shrine I discovered in 1923 by Carter in KV62, the tomb of Tutankhamun (ca. 1333 - 1323 BC).
Piankoff, A.: The Shrines of Tut-Ankh-Amun, Bollingen Series - New York, 1955.
Excegen develops adapted bovine genetics and offers genetic material and support services to producers and the environment, whereas guaranteeing food safety to consumers.
Importance of the Brazilian market
- World's largest commercial bovine herd (~200 million)
- World's largest exporter of beef by volume and value
- Low risk of Bovine Spongiform Encephalopathy (BSE) with grass fed cattle ('Green Beef', 'Green Dairy')
- Low production costs (grass fed cattle cost half as much, per pound, as grain fed cattle)
- Vast native pasture lands (just a fraction of potential pasture land currently in use)
Excegen Nelore research herd
G1G1 parental strain: less productive, but thrifty;
G1G2 terminal strain: optimal heterosis;
G2G2 parental strain: productive, but demanding.
Photograph by S.U. Dani, © Excegen Genetica SA
Thrifty gene provides for survival
Pairwise body weight differences associated with different GH genotypes changed symmetrically from São Carlos (ad libitum pasture/feedlot feeding) to Paracatu (DR-dietary restriction, rough pasture). These changes are reflected in the magnitude and direction of the differences, as measured by Cohen's d effect size measure. G2/G2 and G1/G2 animals performed better than G1/G1 under ad libitum conditions, but under DR the relative performance was inverted: G1/G1 performed better.
Dani et al. 2010. Genet Mol Res 9:1032-1044.
Growth curves of parental strains and terminal strain under nutritional restriction
The large genetic variability of Brazilian zebu cattle affects the optimization of gains. In 2007, Excegen run a feeding test to evaluate the weight gain of different strains of young Nelore bulls (Bos indicus) in the Cerrado biome at Paracatu-MG. The terminal strain gained, on average, 5% more weight than the respective parental strains. This study validated the use of parental strains of bovine cattle selected by marker-assisted selection to produce optimized terminal strains in Brazil.
Dani MA, Heinneman MB, Dani SU. 2008. Brazilian Nelore cattle: a melting pot unfolded by molecular genetics. Genet Mol Res 7:1127-37.
Dani SU, Dani MA, Freire IL, Gouvea SP, Knackfuss FB, Lima FP, Mercadante MEZ, Monteiro E, Paggiaro SMG, Razook AG, and Yehia HC. 2010. Survival of the thriftiest: restricted nurture reveals the thrifty nature of a growth gene in Bos indicus. Genet Mol Res 9:1032-1044.
Dani MA, von Cube M, Freire IL, Suguisawa L, Fischer C, Dani SU. 2012. Synergistic and threshold effects of GH1 and GHR promoter size variation on body growth and fat accrual in young Nelore (Bos indicus) bulls. Genet Mol Res 11:1783-1798.
Dani SU, März W, Neves PM, Walter GF. 2013. Pairomics, the omics way to mate choice. J Hum Genet 58, 643-656.
Dani SU, Oliveira MVM. 2013. Genetics: cattle, cheese and conservation. Nature 502:448.
Brazil Ministry of Science and Technology,
FiNEP-Financiadora de Estudos e Projetos
2004 Technology Innovation Prize.
UFMG-Federal University of Minas Gerais, Brazil,
ICB-Biological Sciences Institute
2004 award ad honorem.
Patent Nr. PI 0207939-9, RPI 8/09/2004, INPI, Brazil. Dani SU/Genon Genética ltda (transferred to PI 0403770-7 with Excegen Genetica SA, 2006): 'Método de seleção de bovinos com maior capacidade de aumento de peso'. (Method for selection of bovines with higher weight gain abilities).
Patent Nr. PI 0403770-7 A, publ. RPI 1843, 2 Maio 2006, p. 80, INPI, Brazil. Dani SU, Dani MA/Excegen Genetica SA: 'Método de seleção de bovinos com maior capacidade de crescimento e ganho de peso.' (Method for selection of bovines with higher growth and weight gain abilities).
Patent Nr. PI 0503427-2 (22), publ. RPI 1892, 10 Abril 2007, p. 76, INPI, Brazil. Dani SU/Excegen Genetica SA: 'Método de seleção de bovinos com tipos metabólicos distintos para crescimento, ganho de peso e qualidade de carcaça.' (Method for selection of bovines of distinct metabolic types for growth, weight gain and carcass quality).
Casamento por DNA (ISTOé Dinheiro, Nr. 356, 06/2004)
Por um Rebanho Melhor (Desafios do Desenvolvimento/IPEA, Ed. 2, 09/2004)
Prêmio FINEP Sudeste tem 15 finalistas. (FINEP, 2004)
Par Perfeito. Análise do DNA Ajuda a Melhorar o Rebanho Bovino (Globo Rural, Nr. 232, 02/2005)
4° MOSTRA E 2ª FEIRA DE TOUROS DA FAZENDA BACURI (Setembro de 2005)
Pequena Empresa é Pioneira no Melhoramento Genético de Bovinos (Página Rural, 09/2005)
Excegen: empresa de genética bovina realiza experimento inédito no país (FirCapital, 07/2006)
Bellman Investe em Prova de Ganho de Peso com Marcadores Moleculares. Prova de Ganho de Peso com Marcadores Moleculares Testa Linhagens Parentais de Bovinos (BeefPoint, 07/2006).
Empresa gerada em incubadora vai à França para criar projeto mundial (JC e-mail 3278, 05/Jun/2007)
Caça ao Sócio (Pequenas Empresas & Grandes Negócios, Edição 223, 08/2007)
Pesquisas genéticas apontam resultados positivos (Gazetadigital, 24/Dec/2007)
Gen Sertanejo Garante Sobrevivência (Alertaparacatu, 06/2010)
Thrifty Gene Provides for Survival (SOS Arsenic, 06/2010)
Genetics: Cattle, Cheese and Conservation. (Nature, 10/2013)
Certificación Genética Busca Salvar Especie en Extinción (SciDev.Net, 11/2013)
Parental strains of cattle are families or stirps of cattle that carry selected genetic traits.
Parental strains are indispensable components of complementary crossbreeding systems aimed at maximizing efficiency and adaptability to the environment.
Crossbreeding is matching genetic diversity to the environment.
Impact for a calf supplier who becomes a packaged-genetics supplier
- This estimation is based on the effects of the progressive substitution of the conventionally selected calf production model with production of young bulls and heifers of parental strains. Sales of parental strain bulls begin at year 3.
- Sales of parental strain heifers begin at year 5. The parental strains are used to generate the terminal strain.
SAMPlus®, Apartagenes® use molecular markers to generate genetic profiles which are then used to maximize the selection of cattle.
PADAM® uses the profiles generated by SAMPlus® to identify the ideal match between individual animals for breeding.
PROLIN® uses the information gained from SAMPlus® and PADAM® to create parental strains of cattle.
RASTREX-MATPlus® is a DNA traceability program with ecotype genetic signature in order to increase food safety and to guarantee socio-environmental conservation.
PARENTPlus® is a parentage testing program coupled with marker-assisted selection.
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Published by Excegen Genetica SA
© 2013 editor and publisher: L.D. Dr. Sergio Ulhoa Dani.
All rights reserved.
Excegen Genética SA is a stock corporation ('Sociedade Anônima') incorporated under the laws of the Federal Republic of Brazil with principal office in the Acangau Valley, Paracatu-MG. It is registered with the district registry ('JUCEMG-Junta Comercial do Estado de Minas Gerais') in Belo Horizonte under NIRE: 313.000.1757-5 , and with the National Taxpayer Registry ('CNPJ') under 05.542.175/0001-44.
The Supervisory Board is comprised of Cmd. Paulo Maurício Serrano Neves (Chairman).
The Scientific Advisory Board is comprised of Dr. Sergio U. Dani (Chairman), Prof. Dr. Hani Camille Yehia, Prof. Dr. Sergio V. A. Campos, Eduardo K. Pedroso, MBA, and Dr. Maria Angela G. C. Dani.
The Management Board is comprised of Mr. Jesiel Gomes (Chairman) and Mr. Otacílio Soares.
Experimental Station at Acangau Valley:
c/o Prof. Márcio José dos Santos
Rua Alamanda, 368
Bairro Jardim Serrano
38600-000 Paracatu MG
Jesiel Batista Gomes
Rua Doresópolis, 1010, sl. 404
Bairro Fernão Dias
31910-170 Belo Horizonte MG
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L.D. Dr. Sergio Ulhoa Dani and Yuri Neves Silveira.
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